El Cazador began in 2003 and ran for six issues before CrossGen's bankruptcy brought the series to a halt.

The company also released a prequel one-shot, El Cazador: The Bloody Ballad of Blackjack Tom, which told the story of the series main villain.

The issue begins as the ship carrying Spanish noblewoman Donessa Cinzia Elena Marie Esperanza Diego-Luis Hidalgo and other members of her family are attacked by a pirate captain named Blackjack Tom.

To accomplish this, she renames her ship El Cazador ("The Hunter") and becomes a pirate herself, dubbed "Lady Sin" by her crew.

The remaining issues of the series will describe the beginnings of Lady Sin's quest as she abandons her privileged past for a life on the high seas.