Its original name was Nuestra Señora de la Pura y Limpia Concepción del Tocuyo.

The surrounding area has good soil and an ideal climate for agriculture, dry and warm with plenty of water available from the Tocuyo River.

When the Spanish arrived they found the Gayones Indians, who inhabited this valley, sowing corn and other agricultural products as cotton and yucca.

After the Spanish came, sugar cane was, for centuries, the biggest crop; but since 1980 vegetables such as tomatoes, onions, chiles, and potatoes are taking its place.

[citation needed] In 1545, Philipp von Hutten, a German captain general representing the Welser bankers of Augsburg, embarked on an expedition in search of El Dorado, leaving Santa Ana de Coro, where Spanish relatives faced hardships.