Mike Pence ran his first political campaign in 1988 for Indiana's 2nd congressional district.
In 2000, he made his third run for public office when he was finally elected to represent the same district.
Forgoing another congressional campaign, Pence entered the 2012 Indiana gubernatorial election, winning the Republican nomination before narrowly defeating Democratic nominee John R. Gregg.
Pence unanimously won his party's nomination in the 2016 gubernatorial election, but withdrew from the race after Republican nominee Donald Trump selected Pence as his running mate in their eventual Electoral College victory against the Democratic ticket of Hillary Clinton and Tim Kaine in the 2016 United States presidential election.
In the 2020 presidential election, Trump and Pence lost to Democrats Joe Biden and Kamala Harris.