Elisabeth of Mecklenburg-Güstrow (3 September 1668 – 25 August 1738), was a German noblewoman member of the House of Mecklenburg and by marriage Duchess of Saxe-Merseburg-Spremberg (during 1692-1731) and Saxe-Merseburg (during 1731-1738).

[1][2][better source needed] In Güstrow on 29 March 1692, Elisabeth married Prince Henry of Saxe-Merseburg, fourth surviving son of Duke Christian I.

Two years later (1694), Henry received the town of Spremberg as his appanage, and took his residence there.

The marriage produced three children, of whom only one survived to adulthood:[3][4][better source needed] Elisabeth became Duchess of Saxe-Merseburg in 1731 after her husband inherited the main domains of the family as their last surviving male member.

She died in Doberlug in 1738, aged 69, having survived her husband for one month.