She next made one voyage as a slave ship in the triangular trade in enslaved people.

Eliza entered Lloyd's Register in 1791 with Middleton, master, Champion, owner, changing to or from BlackB__c_, and trade London–South Seas.

[3] Captain Thomas Middleton sailed from England on 23 January 1791, bound for the Brazil Banks.

[1] She stopped at Rio in July to replenish her food and water, and with sick people.

[6] Captain George Kerr (or Carr) sailed from England on 24 October 1797, bound for the East Coast of Africa.

[b] Lion had been carrying a cargo from Madras and Columbo to England when she had put into Delagoa Bay in distress.

[8] Lloyd's Register for 1799 showed Eliza's master changing from Carr to T. Oxon, and her owner from D. Bennett to Chamley.

[1] Lloyd's Register for 1800 showed Eliza's owner changing from Chamley to Vickers & Co.