When the Cocteau Twins disbanded, Fraser embarked on a moderately low-key solo career and provided guest vocals for other artists.

Fraser has reportedly[citation needed] recorded enough material for a debut solo studio album; however, a release date or further information has not been published.

[7] Music was important and represented an escape; at that time Fraser had portraits of her heroes like Siouxsie Sioux tattooed on her arms.

[7] Fraser then became the vocalist and lyricist in Cocteau Twins in 1981, (a group founded in 1979 by Guthrie and Will Heggie): they spotted her dancing at a club one night and asked her to join their band.

After an on-off phase, the band recorded some tracks which were sent as demos to John Peel and Ivo Watts-Russell of 4AD which led to their signing by the London-based label and a successful career in music.

[12] Guthrie liberally used alcohol and drugs throughout the years they were together,[13] and Fraser had a nervous breakdown during the recording of Four-Calendar Café.

[7] The couple broke up in 1993, but opted to continue a musical relationship mostly due to contractual obligations until 1998, when Cocteau Twins were finally disbanded.

[20] Fraser had a relationship with singer Jeff Buckley[4] and recorded a duet with him, "All Flowers in Time Bend Towards the Sun", written together[21] but never released commercially.

[22] In a 2009 interview with The Guardian, Fraser claimed that she found it "difficult" to think about her former Cocteau Twins bandmates, stating "they were my life, and when you're in something that deeply, you have to remove yourself completely".

She appeared on 4AD house band This Mortal Coil's first release (along with her Cocteau Twins bandmates) where her contributions included a cover version of Tim Buckley's "Song to the Siren".

She provided one-off vocals for acts such as Felt (Primitive Painters), Dif Juz (Extractions LP), The Wolfgang Press, and Ian McCulloch (Candleland and Mysterio).

Fraser has sporadically collaborated with a range of performers, including The Future Sound of London (Lifeforms EP), Elliot Goldenthal, Craig Armstrong (The Space Between Us) and Peter Gabriel (the millennium project OVO).

Billy Howerdel envisioned Fraser as his first option for A Perfect Circle's lead singer, but she was unavailable for the project.

[29][30][31] Under the project Sun's Signature with her partner Damon Reece, Fraser was set to release a self-titled extended-play album on 23 April 2022, via Rough Trade Records.

In 2004, she was invited to participate in an audio exhibit, Shhh..., at London's Victoria and Albert Museum for which she produced a piece called "Expectant Mood", which has not been made commercially available.

Prior to the concerts, she confirmed that she had assembled an album's worth of material and would showcase these at the event in addition to performing re-interpretations of some Cocteau Twins songs.

[44] She also referred to the physical exertion involved in her singing against the wall of sound in many of the Cocteau Twins songs, of which she said it was "like an endurance test.

[45] In addition to Damon Reece on drums and percussion, Fraser's backing band featured three other former or current members of Spiritualized – Sean Cook (guitar), Martin Shellard (guitar), Thighpaulsandra (keyboards) – and two backing vocalists (Jo Goldsmith-Eteson and Lucy Potterton, both from The Swingle Singers).

[46][47][48][49] Sky Arts' 2016 drama series The Nightmare Worlds of H. G. Wells carried a score composed by Fraser and Reece.

They discussed the Cocteau Twins 1988 album Blue Bell Knoll, with all proceeds from the show going to gay rights charity Stonewall.

[54][55] During the conversation, Fraser responded to a question from the audience about a possible collaboration with John Grant, saying "He doesn't need to persuade me!

[19] Fraser, and Cocteau Twins, were said to be "loved" by artist Madonna, and Prince wished to sign the band to his record label.