[3] Jacquemot made her WTA Tour main-draw debut at the 2020 Lyon Open in the doubles draw, partnering Estelle Cascino.

[6] In 2022, she was awarded a third wildcard into the French Open and defeated Heather Watson for her first major match win,[7] before losing in the second round to 21st seed Angelique Kerber.

She returned to the top 150 on 20 May 2024[citation needed] and received a wildcard for the 2024 French Open but lost in the first round to Ana Bogdan.

[15] Jacquemot made her Wimbledon debut as a lucky loser in July 2024, although again suffered a defeat in the first round, this time to Sloane Stephens.

[20] At the same tournament, she won her first WTA 125 doubles title, partnering Margaux Rouvroy, to defeat Erika Andreeva and Séléna Janicijevic in the final.