Desmond is from Lagos in Nigeria and played professional tennis events at the ITF Futures level before coming to the United States to attend college.

On August 12, 2018, Osuigwe won the USTA Girls 18s National Championships which earned her a wildcard entry into the main draw of the US Open.

[7] Osuigwe made her WTA Tour main-draw debut at the 2018 Miami Open, losing to her fellow wildcard and junior rival Claire Liu.

In January 2019, Osuigwe played alongside David Ferrer on the Spain team in the 2019 Hopman Cup, replacing Garbiñe Muguruza who was out due to injury.

[8] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.