She spent her childhood surrounded by her family, playing games and pranks with her siblings Genoveva and Nills in the once quiet streets of Zeballos Cué.

Throughout her career, Elsa Wiezell has been internationally acclaimed and rewarded (even more than in her own native Paraguay) and is considered by many critics and academic scholars to be amongst the most important and influential Spanish-language poets of her time.

Many scholars study her work, including Charles Richard Carlisle (Professor of Spanish Literature at Southwest Texas University in Texas, United States), Carlos Sabat Ercasty Carlos Sabat Ercasty and Norma Suiffet (Professor of Literature at Institute of Superior Studies in Uruguay and Specialist in Spanish Philosophy at the University of Salamanca, Spain).

Water is a recurrent subject, and she also refers to loneliness and to the dreams that usually clash with a reality manifested, for example, as "painful destiny of the body at the earth...".

Carlos Sabat Ercasty has written, "The work of Elsa Wiezell is beautiful and dignified, predetermined by a noble double heroism, marching high and sustaining flight..."[citation needed] She was married to Vicente Ferrer Espínola, and had three children: Lourdes, Armando and Patricia.