Daughter of the laureate Paraguayan writer and philosopher Elsa Wiezell, Espinola's academic background includes the fields of health sciences, international relations, as well as philology and literature, at universities of the United States and Europe.

Her work has been translated into French, Italian, German, English and Portuguese and has been published in France, Spain, United States, Portugal, Germany, Italy, Mexico, Venezuela and Argentina, among other countries.

During that period, Espinola was guest writer at Wellesley College, the University of Miami, and at the Inter-American Development Bank in Washington DC, among other institutions.

She has been a member of the editorial board of Letras Femeninas, the official organism of the Association of Hispanic American Women Literature.

As a result of translation workshops held at the Universities of the Sorbonne, Rouen, and Lausanne in Switzerland, a bilingual edition (Spanish-French) of Espinola's works was published by Adelaide de Chatellus (Editorial Le Temps des Cerises) in France.