In 1909 she returned to Dresden and began teaching at the Städtischen Mädchengewerbe- und Handelsschule (Municipal Girls' Industry and Trade School), where she worked until 1924.
She taught classes in penmanship, correspondence, commodity economics, life skills, mathematics and civics.
She left her teaching job in 1924 and travelled to Italy, where she worked for a year as a nurse and began to pursue commercial photography.
Between 1931 and 1934, Seifert worked for the Hamburg-Südamerikanischen Steam Shipping Company as an onboard photographer on its routes to Norway, Morocco, Spain, Egypt, Palestine and England.
[1] From 1937 she turned her focus away from commercial photography to creating portraits and cityscapes, particularly of Loschwitz, the neighborhood of Dresden where she lived.