They are known for their starring role in Bo Burnham's comedy-drama film Eighth Grade (2018), for which they earned a nomination for the Golden Globe Award for Best Actress – Motion Picture Comedy or Musical.

[2] Fisher began their career at age six, appearing in a 2009 episode of the NBC supernatural drama series Medium.

Fisher appeared in a supporting role in the sports drama film McFarland, USA, which was released in February 2015.

[4] In 2018, Fisher received critical acclaim for their performance as socially-struggling teenage girl Kayla Day in the comedy-drama film Eighth Grade, the directorial debut of comedian Bo Burnham.

For their performance, Fisher earned numerous accolades, including a Golden Globe Award nomination for Best Actress – Motion Picture Comedy or Musical.