Embryonic differentiation waves

The microtubules and microfilaments are in mechanical opposition in a proposed embryonic organelle they called the cell state splitter.

The resolution will begin at one point and spread over the rest of the tissue limited by other mechanical forces at boundaries.

An actual physical wave of contraction has been found which traverses the presumptive neural epithelium of the developing salamander, the axolotl (Ambystoma mexicanum).

[3] Additional waves of both contraction and expansion were also discovered by time lapse photography of axolotl gastrulation.

[4] A biochemical basis for the signal transduction from the cytoskeleton to the nucleus resulting in changes in gene expression was first proposed by Björklund (now Gordon) and Gordon in 1993[5] This would result in a biochemical transduction of the biomechanical signal from the cytoskeleton that is thereby passed on to the nucleus.