In addition to her teaching work, she devoted herself for a long time and diligently to field ethnographic research and collecting regional South Bohemian artifacts.

Her work is reflected in the extensive ethnographic collection in the museum, examples of the life of rural people, folk art and creations of the inhabitants of Soběslavská Blata and Kozácko.

Fryšová collected and bought folk embroideries, costumes and patterns from Blata (she donated 1,500 pieces to the National Museum in Prague), and her collections of the peculiar beauty of Blata were admired in 1895 by visitors to the Czechoslovak Ethnographic Exhibition in Prague and in 1898 to the Ethnographic, School and Industrial and beekeeping exhibitions in Soběslav, held to support the opening of the local museum.

[5][6] During the first twenty years of the 20th century, Fryšová also worked in the town's museum, where she was the first to organize the collection of the ethnographic department and substantially expanded it with a large number of embroideries.

In the Písek museum, historian-professor August Sedláček (a native of Mladá Vožice) and archaeologist-teacher Bedřich Dubský (from Komárov) helped her as colleagues and advisors.