[1] He enrolled in 1814 at the Academy of Fine Arts of Florence, where he took classes with Francesco Carradori and Stefano Ricci (sculptor).
In 1831, Santarelli collaborated on the stucco decoration for the ballroom of the Meridiana building of Palazzo Pitti, built by Pasquale Poccianti.
[2] Also for pantheon- former church of Santa Croce, Santarelli in 1836 sculpted the monument to Giovan Vincenzo Alberti, former minister to the Grand-Dukes of Tuscany.
The artist and patron François-Xavier Fabre commissioned from Santarelli an Immaculate Conception for the cathedral of Montpellier.
In 1840, he completed the statue of Michelangelo for the series of prominent Tuscans displayed in niches on the ground floor courtyard of the Uffizi gallery, commissioned in 1836 by the committee established by Vincenzo Batelli.