Witt is a 2005 graduate of the University of Chicago, where she majored in mathematics with a specialization in computer science.
Her dissertation, Local cohomology and group actions, was supervised by Melvin Hochster.
[2] Witt worked as a Dunham Jackson Assistant Professor at the University of Minnesota from 2011 to 2014, and as a research assistant professor at the University of Utah from 2014 to 2015.
In 20155, she obtained a tenure-track assistant professorship at the University of Kansas.
[1][3] Witt is the 2022–2023 winner of the Ruth I. Michler Memorial Prize of the Association for Women in Mathematics.