After graduation she taught in public school for two years and then moved to Milwaukee, where she worked as a journalist.
In 1894, Blair resigned from the library staff and became assistant to Reuben Gold Thwaites.
Her last work was the translation and editing of documents for The Indian Tribes of the Upper Mississippi Valley and Region of the Great Lakes (2 vols., 1911–12).
This work included Nicolas Perrot's Memoir: The Habits and Customs of the American Indians.
Just days after receiving an advance copy of volume 1 from the bindery,[1] Blair died in Madison, Wisconsin on September 25, 1911.