[16] Culio made his La Serena debut on 26 January 2007, where he started the whole game, in a 1–0 loss against Unión Española.

[21] On 23 June 2007, it was announced that Culio was transferred to the Romanian club CFR Cluj from La Serena, shortly after compatriot Cristian Fabbiani joined the squad.

[29] At the end of the 2007–08 season, making thirty–seven appearances and scoring once in all competitions, Culio earned recognition by his home country.

[31] His performance for the side this season saw him being a subjected of a transfer bid from Russian clubs, such as, FC Moscow and Rubin Kazan.

[32] Despite the transfer bid, he stayed at the club throughout January and his performance continued to impress, earning a praise by his then teammate, Eugen Trică and Gheorghe Hagi.

[48] Despite the move never happened, he, nevertheless, helped the side beat Unirea Urziceni in the Supercupa României, after the match went on penalties following a 2 –2 draw throughout extra time.

[58] On 6 January 2011, Culio signed with Turkish club Galatasaray for reported €2 million where he was wanted by Romanian coach Gheorghe Hagi.

[66] Shortly after the end of the 2010–11 season, new manager Fatih Terim made Culio available for transfer and was expected to leave the club in the summer.

[77] During the 1–1 draw against Beşiktaş on 11 March 2012, he was involved in altercation with teammate Jean-Jacques Gosso; eventually, the situation was resolved and the pair made up.

[78] It was announced on 26 March 2012 when the club decided against taking up options to sign Culio again and expected to return to Galatasaray for the next season.

[83] For the 2012–13 season, Culio signed for Mersin İdmanyurdu on a one-year loan deal on 16 August 2012, with an option of paying the transfer fee of €150K by 15 January 2013.

[88] After scoring his sixth goal against Gençlerbirliği on 17 February 2013, Culio, however, was then sent–off for second bookable offence, in a 2–1 loss against Kayserispor on 3 March 2013.

[89] At the end of the 2012–13 season, making thirty–five appearances and scoring six times in all competitions, Culio left Mersin Idmanyurdu and returned to his parent club.

[98] On 10 January 2014, Culio joined UAE Pro-League side Al Wasl for a transfer fee of 300,000 euros, until the end of the season.

[105] It wasn't until on 4 October 2014 when he made his Las Palmas debut, where he started the whole game, in a 1–1 draw against Sporting de Gijón.

[109] However, in a 5–3 win over Real Zaragoza on 11 January 2015, Culio was sent–off, along with his two teammates, for arguing with referee and officials, leading him to serve a two match suspension.

[119] Four days later, on 6 February 2016, Culio made his Real Zaragoza debut, where he started the whole game, in a 1–0 win over CD Leganés.

[124] Ahead of the match between RCD Mallorca and Real Zaragoza on 5 November 2016, he said family reasons was another factor of his departure from the club.

[136] Culio re–debuted for the club under coach Dan Petrescu on 17 July 2017, in the opening game of the season, a 1–1 draw against FC Botoșani.

[137] He then scored his first CFR Cluj goal since leaving the club, in a 3–0 win over Gaz Metan Mediaș on 29 July 2017.

[142] He played a vital role for the club, along with Ovidiu Hoban, when they helped the side win the league for the first time in six years.

[149] After being sidelined for a month, he made his return from injury against Universitatea Craiova on 1 October 2018 and started the whole game, as the club drew 0–0.

[150] After being suspended for one match for picking up five yellow cards so far this season, Culio scored on his return, in a 5–1 win over Botoșani on 3 November 2018.

[151] However, in a match against CS Concordia Chiajna on 24 November 2018, he was sent–off for the third time this season so far for a second bookable offence, as CFR Cluj won 1–0.

[155] However, between those months, he was suspended on three occasions, including being sent–off twice on the pitch against FC Politehnica Iași and Sepsi OSK Sfântu Gheorghe on 23 February 2019 and 9 March 2019 respectively.

[158] Culio scored the goal that clinched the fifth league title in club history when he converted a penalty against Universitatea Craiova on 12 May 2019.

[167] Culio played his last match at CFR Cluj against FC Voluntari on 21 December 2019 and scored his fifth goal of the season, in a 4–0 win.

[177] Ahead of the 2020 season, Culio was tested positive for COVID-19 on two occasions and did not make a single appearances for the club as a result, as well as, taking care of his wife, who is suffering from cancer.

[179] In March 2021, Culio left Quilmes Atletico Club by mutual consent and announced his retirement from professional football to take care of his wife.

[186] In December 2019, Culio decided to leave CFR Cluj for personal reasons and to return with his family to Argentina.