The film stars newcomers Ajith Chander and Radhika Menon, with S. P. Balasubrahmanyam, Ranjith, Ravikumar, Karunas, Kaka Radhakrishnan, Charuhasan, Fathima Babu and Kamala Kamesh playing supporting roles.
During a trip in Kodaikanal, Jeeva falls under the spell of Priya and gives her a rose for a television show but she slaps him in front of the camera.
One day, Jeeva finds Priya's brother lying in the street after an accident and he admits him to the hospital thus saving his life.
K. R. Jaya who made his directorial debut with Uyirile Kalanthathu (2000) returned with En Uyirinum Melana under the banner of NNT Movie Creations.
Kanal Kannan who choreographed the stunts for the film, also played a rowdy and got to sing a gaana song.