The film began production in March 2016 but suffered delays due to financial issues, and was completed only in September 2018.

Raghu is in his final year of college studying computer science and engineering when he meets an actress Lekha, who is forced to act against her will.

Four years later, Raghu receives a call from Lekha, who tells him that she is with Thiru, who is in trouble, and further asks him to arrive at Mumbai to help him.

Raghu is taken to a room, which is revealed to be Thiru's safe house, where he attacks the cops before being shot by Nagaraj.

Having been saved by the keychain, Raghu discovers a table which has a keyhole that matches with the key Thiru had given him (the keychain was actually a key) and finds a hard drive and a laptop, which reveals about the illegal arms dealings done by many influential people, including Kuberan.

[5][6] Intended to be a quick project, the team expected to finish the shoot within two months starting from March 2016.

[9] The film was announced as a joint production between Menon and P. Madan of Escape Artists Motion Pictures.

[12] Dhanush and Megha Akash shot scenes on the first day, and were joined by Rana Daggubati, who would portray a guest role.

[9] In April 2016, the team travelled to Turkey to film a song and scenes in regions including Istanbul, Ankara, Izmir and Alanaya.

[13][14][15] In October 2016, following a brief production break to allow Dhanush and Menon to finish other ventures, the team shot an action scene with Stunt Silva in areas across Chennai such as Alwarpet and Thiruvanmiyur.

[28] The music composer of Enai Noki Paayum Thota was kept secret by the director, and was simply referred to as "Mr. X".

[29] After much speculations of who being the music composer of the film, it was revealed that "Mr. X" is Darbuka Siva through Menon's Twitter post.

The restrung version of "Maruvaarthai" was released on 17 October and therefore, all the songs of this film are now credited with Darbuka Siva as the composer.

[42] Sowmya Rajendran of The News Minute gave 2.5 out of 5 stars stating "Gautham Menon’s film is stylish but has little substance, his thrillers increasingly feel like he’s remaking the same template over and over again".

[43] M Suganth of The Times of India gave 2 out of 5 stars stating "Enai Noki Paayum Thota is more or less a reiteration of Gautham Vasudev Menon's previous film, Achcham Yenbadhu Madamaiyada.

[44] Gautaman Bhaskaran of News18 gave 2 out of 5 stars stating "Cinema has long ceased to be fantasy and make-believe.

Gautham Vasudev Menon helms this kind of unbelievable existence, his earlier works too have more or less remained in this groove.

[45] Writing for Firstpost, Sreedhar Pillai gave 2 out of 5 stars stating "Enai Noki Paayum Thota is way off the target and should have been shorter.