The film stars Jai, Santhanam and Yami Gautam with Ashutosh Rana, VTV Ganesh, Prem, Nassar, and Thambi Ramaiah in supporting roles.

Tamilselvanum Thaniyar Anjalum, inspired by the 2012 American film Premium Rush,[1] was simultaneously shot in Telugu as Courier Boy Kalyan.

In January 2012, it was reported that Gautham Vasudev Menon would be producing a film starring Jai and Abhinaya, and would mark the directorial debut of Premsai, an erstwhile assistant to Prabhu Deva.

[12][13] S. Saraswathi of Rediff.com wrote, "Tamilselvanum Thaniyar Anjalum may not be a gripping thriller, but has an interesting plot, moves along briskly with some fun moments, has a great background score and high octane stunts in the climax".

[14] Gautaman Bhaskaran of Hindustan Times rated the film 2 out of 5, saying, "Despite knocking at the burning issues of the day and plotted with disarming novelty, Tamil cinema often allows itself be distracted by bland romances, puerile humour and sappy songs" and this was an example of that.

[15] M. Suganth of The Times of India wrote, "With a premise [...] that could make many directors feel envious for not having thought of it first, Premsai gets the first thing right in Tamilselvanum Thaniyar Anjalum, his directorial debut.