Her thesis was a historical survey on the school education of women in the Philippines, a theme that proved apt in light of her later activism as a suffragette.

[5] Alzona pursued further studies in the United States as a pensionado, a scholar funded by the American government.

As early as 1919, Alzona spoke in favor of conferring the right of suffrage to Filipino women, in an article she published in the Philippine Review.

[7] In a newspaper article she wrote in 1926, Alzona lamented the fact that the Philippine legislature, which she described as the "bulwark of conservatism" had yet to consider legislation in favor of women's suffrage.

[8] Alzona's writings during this period bolstered social and political support for women's suffrage, which was finally granted in 1937.

[9] Alzona also wrote biographies on pioneer Filipino women such as Paz Guazon and Librada Avelino, and undertook to translate historical works of Jose Rizal and Graciano Lopez Jaena.

Alzona was a tireless promoter of the works and legacy of her distant relation, the national hero Jose Rizal.