It features multiple alternative versions of Spider-Man that had appeared in various media, where they team up with Morlun to fight Shathra, the Spider-Wasp goddess.
[3] This started in August 2022 with a five-issue anthology miniseries, Edge of Spider-Verse, which was then followed by the core storyline beginning in October 2022 with the launch of the monthly Spider-Man ongoing by Slott and Mark Bagley.
He then meets three figures in spider-print hooded robes who identify Spider-Laird as Donald MacGargan before Madame Web arrives and helps stop them.
On Earth-66, flashbacks reveal the origins of Spider-Rex as a Pteranodon named Pter Ptarker who swapped bodies with the Tyrannosaurus Norranosaurman and gained spider-powers after the two were struck by a spider-filled meteor.
In a Mini-Marvel story, Spider-Man, Miles Morales, and Ghost-Spider are about to play basketball when Spider-UK appears to warn them about the Sisterhood of the Wasp.
On Earth-346, a young girl named Haruka Hida becomes Sakura Spider after a Hydra agent kills her father and is adopted by her Aunt Mei and Uncle Tsutomu.
During the commotion, Spider-Man Noir arrives to seemingly help the heroes, but he then stabs Jessica Drew with a magic dagger which severs her connection to the Web of Life and causes her to disappear from existence.
Spider-Man Noir and the rest of the mutated totems start attacking the 616 Spiders when Anya Corazon arrives with Spider-UK of Earth-834 to take them to the new Spider-Sanctuary on Earth-616 Beta.
Spider-Man meets up with Night-Spider, Hunter-Spider, Sun-Spider, Princess Spinstress and her talking spider companion Webster, and Web-Weaver.
Morlun then attempted to confront Shathra, but was overwhelmed by her strength and ran away to team up with Julia Carpenter, Anya Corazon, and Zarina Zahari.
As the team try to come up with a plan, Miles Morales learns that he was bitten by a Spider-Wasp and is slowly mutating, with Shathra now knowing where the spider totems are.
Julia Carpenter realizes that since Miles Morales is a being from two different Earths (due to the aftermath of "Secret Wars"), he is fighting off the mutation.
Anya Corazon is distraught that Spider-Man is gone, but Night-Spider saves them by triggering a trap that distracts Shathra's forces before escaping.
Miles Morales is thrown in a dungeon where he sees Mary Jane Watson of Earth-18119 (from "Amazing Spider-Man: Renew Your Vows"), Mayday Parker's father, and other Spider-totems who could not be mutated.
Julia Carpenter, Anya Corazon, Night-Spider, and Zarina Zahari arrive with their backup: Peter Palmer, the Spider-Man of Earth-616 Beta.
[14] When Spider-Gwen stabbed Spider-Man, his entire history changed to the point where the spider bit Cindy Moon instead, resulting in the creation of Earth-616 Beta.
When the Burglar arrives to rob Uncle Ben and Aunt May, Peter jumps in front of the bullet and his right leg is paralyzed.
[15] As Shathra grows in power, she creates tendrils that reach across the multiverse, as Silk decides to go through with Morlun's plan with the dagger.
[16] Morlun escapes in a weakened state and Peter uses a machine to send Shathra to another dimension and restore her human form.
Neith arrives and helps Anya Corazon revive Jessica Drew, Kaine Parker, Peter, and the previously unknown Spider-Boy.