The story deals with Spider-Man being in the middle of a conflict between multiple teams of villains, including the Sinister Six and Savage Six, orchestrated by Kindred.

[1] The storyline received mixed reviews from critics with many deeming it as an underwhelming conclusion to Nick Spencer's Spider-Man run due to inconsistent art, sluggish pacing, and Kindred.

Electro shocks the dinosaur, and Doctor Octopus recruits Kraven the Hunter into the Sinister Six by promising him to hunt down the Lizard.

[7] Doctor Octopus coerces Curt Connors into using the Isotope Genome Accelerator on himself which separates him from his Lizard side.

[8] In Las Vegas, Doctor Strange talks with the demon Mephisto at Hotel Inferno over his part in corrupting Peter Parker's soul.

Meanwhile, Peter and Mary Jane Watson are attending the premiere of MJ's new movie which she worked on with Mysterio under the alias of Cage McKnight.

[a] Peter is planning to propose to Mary Jane when the movie is over in front of the press and public, but the Savage Six take the opportunity to attack.

Peter is knocked out by Octavius and awakens in Kindred's lair, where the demon again tortures and taunts him using mirrors containing Mary Jane, Mysterio, and a brutalized Norman Osborn in them.

As Kindred states that this is now a party, Spider-Man sees villains like Black Ant, Boomerang, Chance, Foreigner, Hydro-Man, Jack O'Lantern, Overdrive, Shocker, the Sinister Syndicate (Beetle, Electro II, Lady Octopus, Scorpia, Trapster, and White Rabbit), Slyde, Speed Demon, and Taskmaster racing towards him through the shattered mirrors.

Back at Hotel Inferno, Strange demands Mephisto undo his deal with Spider-Man, but the demon claims his hands are tied.

Stromm has left Norman a deposit box containing a key and instructs him to travel to Europe to face his "legacy" (or rather his "sin" according to Kindred).

[10] As Doctor Octopus gets frustrated that Kindred has not given him the answers he needed yet while leading the Sinister Six which Kindred comments about, Spider-Man is struggling in the graveyard avoiding the attacks of Foreigner, Taskmaster, Black Ant, Chance, Jack O'Lantern, and Slyde who are out to make sure that Spider-Man doesn't leave the graveyard alive.

[11] Badly wounded, Peter is relieved to find the Black Cat, Wolverine, and Human Torch have arrived to help, unaware they are Mysterio, Lizard, and Electro in illusion disguises created by the former.

Doctor Octopus briefly hesitates, but mounting pressure from the rest of the Sinister Six compels him to act though this buys Peter enough time to break free.

Boomerang also has a change of heart and helps Peter escape as all of the assembled six-member teams brawl for the right to claim Spider-Man's life.

From Sin-Eater's reanimated corpse springs forth demonic centipedes that seek out and take possession of Grey Gargoyle, Living Laser, Whirlwind, Juggernaut, and Morlun.

Through a series of flashbacks dating back to his childhood, it is revealed that Harry Osborn's entire life of misery, addiction, despair, and even death were defined by a deal his father struck with Mephisto to make his life much more prosperous at the cost of his own son's soul, inevitably also tying Norman's descent into insanity and criminal career to the demonic overlord.

Doctor Octopus activates his transducer that he slipped in Black Ant's helmet and successfully disables the centipedes, knocking out everyone except himself and Spider-Man.

Doctor Strange asks what will become of Spider-Man and Mephisto answers that while Peter has walked away from a war where the odds were stacked against him, he should enjoy the small victories as a much bigger loss is imminent.

Equipping himself with a goblin glider and pumpkin bombs, Harry helps Peter, Norman, and Mary Jane battle the Kindred Twins, but is eventually killed.

With Kindred vanquished and the "Sinister War" over, Peter and Mary Jane return home to heal and face the dawn of a new day together as a loving and unbreakable couple.