Endomysium is the deepest and smallest component of muscle connective tissue.

This thin layer helps provide an appropriate chemical environment for the exchange of calcium, sodium, and potassium, which is essential for the excitation and subsequent contraction of a muscle fiber.

Endomysium combines with perimysium and epimysium to create the collagen fibers of tendons, providing the tissue connection between muscles and bones by indirect attachment.

[5] Collagen is the major protein that composes connective tissues like endomysium.

[8] They do not cause any direct symptoms to muscles, but detection of EMA is useful in the diagnosis of the disease.