The Ene is formed at 12°15′45″S 73°58′30″W / 12.26250°S 73.97500°W / -12.26250; -73.97500 at the confluence of the Mantaro River and the Apurímac River, circa 400 m above sea level, where the three Peruvian Regions Junín, Cusco, and Ayacucho meet.
The river flows in a northwesterly direction at a total length of 180.6 km (112.2 mi).
The proposed 2,200-megawatt Pakitzapango hydroelectric dam would flood much of the Ene River valley.
[1] Protests by the Central Ashaninka del Rio Ene (CARE, Asháninka Center of the Ene River) and Ruth Buendia (president since 2005) have halted the construction.
[1][2] For her efforts, Buendia was awarded the Goldman Environmental Prize in 2014.