Enigmaticolus desbruyeresi is a species of sea snail, a marine gastropod mollusc in the family Eosiphonidae, the true whelks and their allies.

[1] Easily distinguishable from all other Enigmaticolus species by the complete lack of a subsutural ramp.

Also exhibits weak spiral cords on the base.

[2] Found in hydrothermal vents in Manus, North Fiji, and Lau basins in the southwestern Pacific and off Luzon, Philippines.

Individuals have been known to live 1456–2750 m deep.