[2] It appears to cover the same territory as the former Ennedi Est Department.

The region's northern border lies within the Aouzou Strip, historically a point of dispute between Chad and Libya.

[4] Am-Djarass is the regional capital; other major settlements include Bahaï, Bao Billiat, Kaoura and Mourdi.

[5] The main ethnolinguistic groups are the Dazaga Toubou and the Zaghawa.

[6] Ennedi Est Region is divided into two departments:[2]