Having begun his career in his native Zambia, Mwepu signed for Austrian club Red Bull Salzburg in 2017[4] before moving Brighton & Hove Albion in 2021.

[10] He made his competitive debut on 14 August in the opening game of the 2021–22 season away at Burnley where he was replaced by Adam Lallana at half time of the 2–1 victory at Turf Moor.

[15] On his first start since his return from injury Mwepu scored and made an assist for Trossard's opener in the 2–1 away win at Arsenal on 9 April, to help Brighton end their seven-match run without a victory.

[16] Graham Potter spoke that Mwepu has a "slight injury in his groin which probably means that will be him for the rest of the season," after picking up the knock during the 3–0 away victory at Wolverhampton Wanderers on 30 April.

[19] Mwepu managed to recover in time to appear as a substitute in the last game of the season, a 3–1 home victory over West Ham United, with Brighton achieving their highest top flight finish in ninth place.

[citation needed] After retiring from professional football due to his heart condition, Brighton announced on 30 December that Mwepu had been appointed to serve in the role of under-9s coach in their academy from January 2023.