Synthesis-wise, the SQ-80 introduced the so-called 2nd Release, a low-cost solution to simulate reverb-like effects.

The SQ-80 was the first Ensoniq product to feature their patented Polypressure Keyboard technology.

Since the keyboard does not use mechanical sensors for detecting velocity and pressure, it is immune to contact problems (which ESQ-1 and Mirage suffered from) and pressure sensor wear-out (like conventional keyboards).

Because of the hardware similarities, the SQ-80's operating system was later back-ported to the ESQ-1 to become the latest ESQ-1 OS Version 3.5, which is almost identical to SQ-80 OS 1.8 apart from the hardware-specific features (additional waveforms, floppy routines, and keyboard control).

[citation needed] On the SQ-80 and ESQ-1, a large fluorescent display consisting of two rows of 40 alpha-numeric characters shows many parameters at once for a given section, and buttons placed over and under it give instant access to each one.