Resistance is due to a chromosomal gene, vanC, which encodes for a terminal D-alanine-D-serine instead of the usual D-alanine-D-alanine in cell wall peptidoglycan precursor proteins.

[4] That is a separate mechanism than the vancomycin resistance seen in VRE isolates of E. faecium and E. faecalis which is mediated by vanA or vanB.

[7] A study published in 2018 found that this infectious gut bacterium can translocate (spread) to other organs such as the lymph nodes, liver, and spleen, triggering an autoimmune reaction in humans and mice.

The autoimmune reaction was found to be suppressed when an intramuscular vaccine or antibiotic was administered.

[11] The antibiotics linezolid,[10] daptomycin and gentamicin,[11] levofloxacin, and penicillin G are effective against the bacteria, depending on the specific isolate.