Insects, human, vertebrates, and arthropods serve as natural hosts.

The genome is exceptionally large, around 250-380kb in length and the virion diameter is around 350 nm.

Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.

Assembly of progeny virions starts in cytoplasmic viral factories, producing a spherical immature particle.

Mature virion can be occluded in spheroids composed of spheroidin proteinhost receptors, which mediates endocytosis.