The mayfly can be found throughout the United States in the Rockies, Midwest, and in the Great Lakes region.

[3] The nymphs of the species burrow and can be found the same time as the Green Drake (Ephemera guttulata) mayflies, which the species acts similar to; if one trout stream has a hatch of E. simulans, there might also be a hatch of E.

[2] The mayfly hatches annually at Skaneateles Lake, where fly fishermen arrive from Central New York and further to fish at.

It hatches from mid-June to mid-July and the nymphs emerge from the sand and silt bottoms of streams where trout are.

[7] When using an artificial fly of its adult stage, the silhouette and presentation are more important than it being the same color.