[11] In 2011, the series spawned a spin-off web-series, Your Lupine Life, where Ephraim reprised the role of Seth, as well as writing the episode in which he appeared.
[12] As a tie-in to the two web-series, Ephraim also wrote and published a book, Archie Hartigan & The Frost Wolf, a young adult fiction novel set in the same universe as Seth On Survival and Your Lupine Life.
From 2011 to 2016, Ephraim was a member of the Toronto sketch comedy troupe The Rocket Scientists alongside Brandon Hackett, Kevin MacNeil, and Chris Small.
[14] Later that year, Ephraim took on the role of Hedwig in the Lower Ossington Theatre's production of Hedwig & the Angry Inch, in a performance Toronto's Now Magazine said "achieves emotional depth, telling stories of love and betrayal, revealing a poignant loneliness beneath the makeup, sparkly costumes and iconic blond wig," and that "Ellis has the manic energy and singing chops to deliver in this difficult role.
[18] In 2018, Ephraim reunited with his Degrassi co-stars to appear in the music video for Drake's single "I'm Upset", reprising his role as Rick Murray.