His Superiors always entrusted him with the affairs to look for new foundations for the Capuchin province of Tours, thus he traveled to Sidon, Beirut, Damascus, Aleppo, Diyarbakir, Mosul, Baghdad, Isfahan and Basra.
Because, in 1639, the French Capuchin Father Zeno de Beauge founded the first mission for the Propaganda Fide in India with a lot of opposition from the Padroado clergy.
The English who founded the city of Madras in 1639, requested him earnestly to stay there for the spiritual benefits of the Portuguese Catholics.
[7] Ephrem de Nevers returned to his mission of Madras and served with a great missionary spirit and brought many souls to the Christian faith.
Having served 53 years as missionary in Madras, Ephrem de Nevers increased his flock from 40 to 8000[9] and he died on 13 October 1695 and he was buried in the church of St. Andrew in Fort St.