Epidendrum friderici-guilielmi is a species of orchid in the genus Epidendrum which grows naturally at altitudes of 1.7—3.0 km.

Epidendrum friderici-guilielmi is a reed-stemmed Epidendrum, with tall, closely spaced stems covered by distichous, tubular sheaths.

On the upper part of the stem, the sheathes bear broad oblong leaves, up to 3 dm long by 1 dm wide, which are pointed at the end.

The very large peduncle[2] erupts from a single elongate spathe at the apex of the stem.

The racemose inflorescence bears many purple to crimsonflowers, with the widely opened segments as much as 1 dm from the floral axis.