By the order of Ivan the Terrible, the monastery became a collection facility for metayage, quitrent, and fodder.
In 1632, the Epiphany monastery was granted an exclusive right for tax free floating of a certain amount of building materials and firewood.
Vasili III, Ivan the Terrible, Boris Godunov, the Romodanovsky boyars, Xenia Repnina, and others donated some of their sizeable estates to the monastery.
A splendid specimen of the Muscovite baroque style, it incorporated some notable medieval sepulchres.
In 1788, the Epiphany monastery was proclaimed a residence of the vicarian bishop of the Moscow bishopric.
The monastic facilities were first transformed into a campus for students of the Mining Academy and workers, engaged in the subway construction, and later - into metalworks.