In the late 17th century, the monastery's learned administrators such as Symeon of Polotsk and Sylvester Medvedev had it transformed into a hotbed of enlightenment.
Between 1687 and 1814, it was home to the Slavic Greek Latin Academy, Russia's first secondary education establishment.
There is a memorial plaque in honor of its most famous student, Mikhail Lomonosov.
After Lomonosov founded the Moscow University in 1755, the academy declined in importance.
After the October Revolution, the monastery's distinctive belltower was pulled down and the remaining buildings were given to the Moscow State Institute for History and Archives.