The theatre, a Grade II listed building,[1] closed on 30 June 2023 following a decision by Liverpool City Council to end its financial support to the venue.

One of the main reasons for the acquisition of the theatre from the Cranes was due to Brian Epstein opening up North End Music Store (NEMS) in Whitechapel, introducing competition they had previously not had to consider.

This caused a huge outcry around the city and many performers, including Dame Judi Dench, were part of the campaign to keep the theatre open.

Upon reopening in 2011 after the £1.2m refurbishment (as a result in closing in 2005 for health and safety reasons) the theatre was dedicated to the memory of Beatles manager Brian Epstein, for his contributions to the city's cultural and musical scene.

After 112 years of being a staple of Liverpool's Arts and Culture, and being closed down for the fourth time, the Epstein is to lay dormant for the foreseeable future until it is revived once again, truly earning its title as "The Theatre that Refuses to Die."

The theatre was chosen for a special BBC filming of Steve Coogan's Paul & Pauline Calf's Cheese and Ham Sandwich programme.