It was built in 1863 on the present-day Hoogstraat ("High Street"), on the site where the Beurstraverse ("Stock Exchange Traverse") currently stands.

In 1866 the hospital moved to the Villa Belvedere, bought by the municipality of Rotterdam at Dirk Smitsstraat 4.

As an academic hospital, in addition to direct diagnosis and treatment of patients, it also pays attention to scientific research.

Parents and their children can request a guest room in the Ronald McDonald House Sophia Rotterdam.

On 10 September 2015, Ollimania and its creators Hein Mevissen and Diederiekje Bok donated[4] a huge Olli statue to the Sophia Children's hospital.