He played college football for the Miami Hurricanes and was selected ninth overall by the New York Giants in the 2015 NFL draft.

Flowers played offensive tackle at the University of Miami and in the early part of his NFL career prior to switching to guard in 2019.

A native of Miami, Flowers originally attended Krop High School in the Ives Estates, where he was a basketball standout and did not focus on football until his junior year.

[1] For his senior year, he transferred to Norland High School in Miami Gardens,[2] where he joined a talented varsity that featured blue chip running back Duke Johnson.

[14] In 2018, former offensive line teammate and NFL analyst Geoff Schwartz accused Flowers of "quitting" on the team, of missing multiple blocks, and of having poor technique.

On September 23, 2018, the Giants decided to bench Flowers in favor of Chad Wheeler at right tackle after his continued struggles.

[19] On October 12, 2018, the Jacksonville Jaguars signed Flowers to a one-year contract after Josh Wells was placed on injured reserve.