Amukamara was also a member of the Jacksonville Jaguars, Chicago Bears, Las Vegas Raiders, Arizona Cardinals and New Orleans Saints.

On March 10, 2011, he participated at Nebraska's pro day along with teammates Niles Paul, Roy Helu, Alex Henery, Eric Hagg, Dejon Gomes, and 12 others.

He finished his rookie season with 14 combined tackles (12 solo), three pass deflections, and an interception in seven games and zero starts.

On January 8, 2012, Amukamara made his postseason debut and recorded two combined tackles in a 24–2 victory over the Atlanta Falcons during the NFC wildcard game.

The Giants went on to defeat the Green Bay Packers 37-20 and the San Francisco 49ers 20–17 in overtime winning the NFC Championship.

Throughout his rookie season in 2011, he was the New York Giants' third cornerback on their depth chart, behind Aaron Ross and Corey Webster.

[40] He competed with Aaron Ross, Terrell Thomas, Jayron Hosley, and Justin Tryon for the starting cornerback job.

[42] On September 20, 2012, he made his 2012 season debut, recording a tackle and a pass deflection in a 36–7 defeat of the Carolina Panthers.

[39] In training camp, Amukamara competed with Aaron Ross, Corey Webster, and Jayron Hosley for the starting cornerback position.

[45] On September 15, 2013, Amukamara recorded a career-high ten solo tackles and defended a pass during a 23–41 loss to the Denver Broncos.

On September 29, 2013, he collected three combined tackles, defended two passes, and intercepted Kansas City Chiefs' quarterback Alex Smith in a 7–31 loss.

[46] He finished the season with a career-high 85 combined tackles (76 solo), 14 pass deflections, and an interception in 16 games and 16 starts.

[49] On September 14, 2014, he recorded a season-high nine combined tackles and a pass deflection during the Giants' 14–25 loss to the Arizona Cardinals.

In Week 4, Amukarmara recorded three combined tackles, two pass deflections, and intercepted Washington Redskins' quarterback Kirk Cousins in a 45–14 victory.

[39] Amukamara started the Giants' season-opener against the Dallas Cowboys and recorded a season-high eight combined tackles during a 26–27 loss.

In Week 3, he made a season-high eight combined tackles, three pass deflections, and intercepted Washington Redskins' quarterback Kirk Cousins during a 32–21 victory.

[47][53] Amukamara competed against Davon House, Jalen Ramsey, Aaron Colvin, Dwayne Gratz, and Josh Johnson throughout training camp for the starting cornerback job.

Head coach Gus Bradley named Amukamara the starting nickelback, alongside Davon House and Jalen Ramsey, to begin the season.

[47][55] Throughout training camp, he competed with Marcus Cooper, Sherrick McManis, Bryce Callahan, and Kyle Fuller for the Bears' starting cornerback position.

[57] In Week 3, he made his Chicago Bears debut and collected three combined tackles and defended two passes in a 23–17 overtime victory over the Pittsburgh Steelers.

[58] On September 17, 2018, Amukamara recorded his first career interception for a touchdown on quarterback Russell Wilson in the 24–17 victory over the Seattle Seahawks on Monday Night Football.

In week 14 against the Los Angeles Rams, Amukamara intercepted Jared Goff which sealed a 15-6 Bears win.

[60] In week 4 against the Minnesota Vikings, Amukamara made 2 tackles and forced a fumble off Stefon Diggs in the 16–6 win.

[61] In week 5 against the Oakland Raiders, he recovered a fumble forced by Sherrick McManis on Trevor Davis at the goal line in the 24–21 loss.

On August 24, 2023, Amukamara signed a one-day contract with the New York Giants to retire as a member of the team that drafted him.