After tossing just 6 innings in 4 games in 2002, his first official year, DuBose looked to be a career minor leaguer for good.

However, when the Baltimore Orioles needed a spot starter for a game against the Royals in May 2003, they recalled DuBose from Triple-A Ottawa and he did not disappoint, tossing 6 innings of 3-hit, 2-run ball.

Unfortunately for the Orioles' organization, DuBose took a step back as a full-time starter in 2004, compiling a 6.39 ERA in 14 games while allowing 12 home runs.

DuBose signed with the Cleveland Indians in late May 2007, spending the season with the Buffalo Bisons of the International League.

For the 2008 season, he played for the independent Bridgeport Bluefish of the Atlantic League before his contract was purchased by the Los Angeles Dodgers on August 3, 2008; he was assigned to Double-A Jacksonville.