She was a fan of Archie Comics, and names Dan DeCarlo and Samm Schwartz among her earliest influences for their distinctive styles.

She was also a fan of the DC Comics series Young Heroes in Love, which showed her how superheroes could be adapted into different genres and story types.

[5] Graeme Virtue of The Guardian praised her artwork on the series, saying, "The real selling point is the gorgeous, cartoon-influenced art by Erica Henderson, which looks like nothing else Marvel is putting out at the moment".

[6] Henderson reunited with Squirrel Girl writer Ryan North to create a YA graphic novel titled Danger and Other Unknown Risks.

When working on Squirrel Girl, Henderson employed a template different from the ones she uses for other books, which had extra space at the bottom for text.