A podcast sequel to the comic book series, Marvel's Squirrel Girl: The Unbeatable Radio Show, launched in April 2022.

[3] Marvel registered a trademark for Squirrel Girl in July 2014, leading to speculation that the character would appear in a future film or television series, such as Agents of S.H.I.E.L.D.

[4][5] In October, Entertainment Weekly revealed that Squirrel Girl would star in a solo series by writer Ryan North and artist Erica Henderson.

[6] Entertainment Weekly called it a "quietly bold move for Marvel", publishing "a female-centric comic that's intended to appeal equally to canon-heads and newcomers".

[6] Starting in May 2015, the Secret Wars crossover storyline affected a number of Marvel comics and characters.

It is written by North, directed by Giovanna Sardelli and stars Milana Vayntrub as Squirrel Girl; the series is produced by Radio Point.

[3][10] Additionally, North "wrote an all-new 'Squirrel Girl' vertical comic tie-in" which debuted on Marvel Unlimited.

[13] During a battle with Ratatoskr, Squirrel Girl teams up with Thor (Jane Foster), Odinson and Loki to defeat the Asgardian demon.

She then meets Doctor Doom (from 1991 who was just defeated by Squirrel Girl and Iron Man in Marvel Super-Heroes Winter Special).

She has abducted human-like creatures, like Beast, Rocket Raccoon, the missing cat built into a cyborg, and a Squirrel that was fused with Wolverine's DNA and adamantium claws and was going to release them in a high stakes hunt.

[19] Kraven and Doreen join them, but Sharon has a superpowered Cosplay outfit with Angel's wings, Iron Man's repulsors, Hulk fists, and Thor's hammer.

[21] Reviews of issue #2 were positive, with PopMatters calling it a "breath of fresh air: funny, charming, quirky, strong, brave, unbeatable".