Productions were performed from 1915 to 1919 at the Reed Hotel near North Park Row.

The company occupied the Penn Movie House in Wesleyville, Pennsylvania from 1965 to 1975, when fire regulations forced the closing of the building, at which time performances of the "Brave Little Theatre Without A Home" were held at an assortment of local venues.

In 1983, the company purchased and renovated the Strand Theatre at 13 West 10th Street in downtown Erie, which is its present home.

Erie Playhouse hosts Youtheatre, an opportunity for students to learn about the stage behind the scenes, in classes, and in a long-running summer camp.

PLAYtime uses the arts as a vehicle to make a meaningful connection with the stories from Dolly Parton’s Imagination Library with, in and through the use of song, drama, movement, and visual arts, stories come alive and create purposeful shared reading experiences.