Ernesto Ruffini (19 January 1888 – 11 June 1967) was an Italian cardinal of the Catholic Church, who served as Archbishop of Palermo from 1945 until his death, and was elevated to the cardinalate in 1946 by Pope Pius XII.

Ruffini received his episcopal consecration on the following 8 December from Giuseppe Cardinal Pizzardo, with Archbishop Francesco Duca and Bishop Domenico Menna serving as co-consecrators.

[2] During his tenure as Palermo's archbishop, he supported Francisco Franco,[3] but protested against communism[4] and anti-Mafia activist Danilo Dolci.

He also demanded that the Sicilian bandit Salvatore Giuliano cease murdering within Palermo,[1] and was wary of implying that the Mafia was Sicily's main problem.

During the discussion on the Council's proposed declaration against anti-Semitism, Cardinal Ruffini accused the document of being overly kind to the Jews, whom he saw as hostile to Christianity.