[4][5][6] He has anchored the evening news at four flagship network stations in New York: UPN 9 (now My9), ABC 7, CBS 2 and FOX 5.

[18] In 2004 from Cuba, he reported on Fidel Castro’s revolutionary reign and has interviewed other noted world leaders including; Presidents Jimmy Carter, George H.W.

Bush and Bill Clinton, also Soviet President Mikhail Gorbachev and South African bishop Desmond Tutu.

[22] He has performed on-camera roles as himself in Hollywood motion pictures such as the Independence Day, Summer of Sam, Run All Night and The Yards.

[23] After graduating from Northeastern University with BA degree in Sociology, Anastos worked as a newsman at WRKO and WROR in Boston.

In 1982 he was replaced on the 5:00 and 11:00 pm newscasts by Tom Snyder, who joined WABC following the cancellation of his NBC late-night program.

[34] From 1995–2000, Anastos became involved in radio and TV broadcast ownership while also anchoring and hosting various assignments including, WWOR-TV and Lifetime's Our Home.

[11] In June 2019, Anastos decided to relinquish his anchoring duties at the WNYW-TV to enroll at Harvard Business School to study a curriculum of leadership and management courses.

[40][11] He has completed additional studies at Harvard Business School and holds honorary doctorate degrees from Marist College, Sacred Heart University and New York Institute of Technology.