In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment.

The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.

[2] According to some sources, there are two conditions included on a spectrum of this same disease process: In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.

[3][4] However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.

Orphanet Journal of Rare Diseases 2010, 5:39 doi:10.1186/1750-1172-5-39