Together with other species in Mimulus section Erythranthe, it serves as a model system for studying pollinator-based reproductive isolation.

[7] It is a fairly large, spreading, attractive plant which bears strongly reflexed, nectar-rich red or orange-red flowers and toothed, downy leaves.

It is native to the West Coast and Southwestern United States and Baja California, and is generally found at low elevation in moist areas.

[9] Its blooms and large nectar load attract hummingbirds, whose foreheads serve as the pollen transfer surface between flowers.

In the area where it overlaps with its sister species, Erythranthe lewisii, reproductive isolation is maintained almost exclusively through pollinator preference.